Tuesday, December 20, 2011

Alarm, disbelief as Dutch lab creates highly contagious airborne H5N1 killer flu "novel" virus

Fear of fake terrorism as university prepares to publish key details:  The editor made this prediction in 1997 in Brevig Mission Alaska and has been reporting on it since in the hope someone will wake up


The Independent
By Steve Connor
12/20/2011

A deadly strain of bird flu with the potential to infect and kill millions of people has been created in a laboratory by European scientists – who now want to publish full details of how they did it.

"Dr. Death" Johann Hultin dug up H5N1 in Alaska, 1997
The discovery has prompted fears within the US Government that the knowledge will fall into the hands of terrorists wanting to use it as a bio-weapon of mass destruction.

Some scientists are questioning whether the research should ever have been undertaken in a university laboratory, instead of at a military facility.

    The US Government is now taking advice on whether the information is too dangerous to be published.


    "The fear is that if you create something this deadly and it goes into a global pandemic, the mortality and cost to the world could be massive," a senior scientific adviser to the US Government told The Independent, speaking on condition of anonymity.

     Dutch scientists carried out the controversial research to discover how easy it was to genetically mutate H5N1 into a highly infectious "airborne" strain of human flu. They believe that the knowledge gained will be vital for the development of new vaccines and drugs.

     But critics say the scientists have endangered the world by creating a highly dangerous form of flu which could escape from the laboratory – as well as opening a Pandora's box for fanatical terrorists wishing to make a bio-weapon.

    The H5N1 strain of avian influenza has killed hundreds of millions of birds since it first appeared in 1996, but has so far infected only about 600 people who came into direct contact with infected poultry.

   What makes H5N1 so dangerous, though, is that it has killed about 60 per cent of those it has infected, making it one of the most lethal known forms of influenza in modern history – a deadliness moderated only by its inability (so far) to spread easily through airborne water droplets.

    Scientists are in little doubt that the newly created strain of H5N1 – resulting from just five mutations in two key genes – has the potential to cause a devastating human pandemic that could kill tens of millions of people. The study was carried out on ferrets, which when infected with influenza are the best animal "model" of the human disease.

Only known anti-virals that kill H5N1:  Oseltamivir and Ribavirin
The details of the study are so sensitive that they are being scrutinised by the US Government's own National Science Advisory Board for Biosecurity, which is understood to have advised American officials that key parts of the scientific paper should be redacted to prevent terrorists from using the information to reverse-engineer their own lethal strain of flu virus.

    In an unprecedented move, the Biosecurity board is believed to have told the US Government that there is a serious possibility of potentially dangerous information being misused if the full genetic sequence of the mutated H5N1 virus were to be published in open scientific literature.

   A senior source close to the Biosecurity board, who wished to remain anonymous, told The Independent that the National Institutes of Health, which funded the work, is about to make a decision on how much of the scientific paper on the H5N1 super strain should be published, and how much held back.

    "There are areas of science where information needs to be controlled," the scientist said. "The most extreme examples are, for instance, how to make a nuclear weapon or any weapon that is going to be used primarily to kill people. The life sciences really haven't encountered this situation before. It's really a new age."

    The study was carried out by a Dutch team of scientists led by Ron Fouchier of the Erasmus Medical Centre in Rotterdam, where the mutated virus is stored under lock and key, but without armed guards, in a basement building.

    Dr Fouchier, who declined to answer questions until a decision is made on publication, said in a statement released on the university's website that it only took a small number of mutations to change the avian flu virus into a form that could spread more easily between humans.

"Old" H5N1 is present in Indonesia and other ASEAN countries
"We have discovered that this is indeed possible, and more easily than previously thought. In the laboratory, it was possible to change H5N1 into an aerosol-transmissible virus that can easily be rapidly spread through the air," Dr Fouchier said. "This process could also take place in a natural setting.

    "We know which mutation to watch for in the case of an outbreak and we can then stop the outbreak before it is too late. Furthermore, the finding will help in the timely development of vaccinations and medication."

     A second, independent team of researchers led by Yoshihiro Kawaoka of the universities of Wisconsin and Tokyo is understood to have carried out similar work with similar results, which has underlined how easy it is to create the super virus with a combination of deliberate mutations and random genetic changes brought about by passing avian flu manually from the nose of one ferret to another.

    "It's scary from a number of different angles. You want to have the vaccines and therapeutics in place, and you need to have a much information as you can about a particular virus, but you also worry about it from a biosecurity perspective."

Yoshihiro Kawaoka
The Dutch virologist started as an expert in HIV, having received his PhD from the University of Amsterdam in 1995. After research at the University of Pennsylvania School of Medicine, he began a new career in the virology department at Erasmus Medical Centre in Rotterdam, studying the molecular biology of the influenza A virus.

    At a conference in Malta in September, he described his work as something that was "really, really stupid," but ultimately useful for the development of vaccines.


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