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Saturday, February 11, 2017

Antibiotic Resistance: "Superbugs" Can Be Killed By Modifying Existing Drugs

Extreme care needs to be taken in quickly disinfecting minor wounds and insect bites in tropical environments - especially among children, the elderly, immune compromised and diabetics  

THE INDEPENDENT
By Ian Johnston
02/03/2017

In the evolutionary arms-race between deadly bacteria and the antibiotics used by doctors to kill them, the bugs have very definitely been gaining the upper hand in recent years.


But, amid growing reports of bacteria resistant to even the ‘last resort’ antibiotics, comes the news that scientists have found a new way that some existing drugs can still be effective.

Normally antibiotics must bind to a bacteria cell in order to kill it, like putting a key in a locked door.

But the researchers found that one drug exerted such a strong physical force on the bacteria that it “tore the door off its hinges”.


The hunt is now on for other antibiotics with similar properties to create a “new generation” of drugs capable of defeating even the most resistant superbugs. The UK was instrumental in organising a meeting at the United Nations to discuss the issue.

One of the researchers, Dr Joseph Ndieyira, of University College London, said: “Antibiotics work in different ways, but they all need to bind to bacterial cells in order to kill them.

“Antibiotics have ‘keys’ that fit ‘locks’ on bacterial cell surfaces, allowing them to latch on. 


Coral reef cuts can and often do turn septic within hours if not immediately and aggressively treated

“When a bacterium becomes resistant to a drug, it effectively changes the locks so the key won’t fit any more. 

“Incredibly, we found that certain antibiotics can still ‘force’ the lock, allowing them to bind to and kill resistant bacteria because they are able to push hard enough. 

“In fact, some of them were so strong they tore the door off its hinges, killing the bacteria instantly.”

The study tested a powerful antibiotic called vancomycin, used as a last-resort treatment for infections like MRSA, and another called oritavancin, used to treat skin infections.

“We found that oritavancin pressed into resistant bacteria with a force 11,000 times stronger than vancomycin,” says Dr Ndieyira. 

“Even though it has the same ‘key’ as vancomycin, oritavancin was still highly effective at killing resistant bacteria. 

“Until now it wasn’t clear how oritavancin killed bacteria, but our study suggests that the forces it generates can actually tear holes in the bacteria and rip them apart.”


Tropical puncture wounds are some of the worst and must be immediately attended to in order to avoid infection, removal of all foreign material and debridement if necessary in addition to oral antibiotics

This way of killing bacteria has not been seen before.

“Oritavancin molecules are good at sticking together to form clusters, which fundamentally changes how they kill bacteria,” Dr Ndieyira said.

“When two clusters dig into a bacterial surface they push apart from each other, tearing the surface and killing the bacteria. 

“Remarkably, we found that conditions at the bacterial surface actually encourage clustering which makes antibiotics even more effective.”


Animal bites are a medical nightmare anywhere, transmitting both
bacteria and viruses: Look, don't touch or feed
The researchers have now developed a mathematical model that could be used to screen for new antibiotics that have the same “brute force” approach.

“Our findings will help us not only to design new antibiotics but also to modify existing ones to overcome resistance,” Dr Ndieyira said. 

“Oritavancin is just a modified version of vancomycin, and now we know how these modifications work we can do similar things with other antibiotics. 

“This will help us to create a new generation of antibiotics to tackle multi-drug resistant bacterial infections, now recognized as one of the greatest global threats in modern healthcare.”

The growth of antibiotic resistance has been driven partly by over-prescription of the drugs for conditions like the common cold, which is a virus, not a bacterium, and is therefore unaffected. 

Antibiotics have also been used in agriculture to boost the growth of livestock.

The researchers' findings were published in the journal Scientific Reports.



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The real truth on 9/11 slowly continues to bleed out

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The Empire and the inevitable fall of the Obama criminal regime

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STRATFOR Editor’s Note: This installment on the United States, presented in two parts, is the 16th in a series of STRATFOR monographs on the geopolitics of countries influential in world affairs.

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By Robert S. Finnegan

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The 5th Estate has just purchased a library on H5N1 "Novel" virus pandemics, there are dozens of PDF and Exel documents we feel will assist you in saving lives following intentional releases of the H5N1 and now MERS viruses; we will begin by printing those that appear to be extremely relevant here: H5N1 Kobe-Kawaoka-Ernala series continues soon with more "Smoking Gun" e-mails from Teridah Ernala to The 5th Estate . . .

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On October 12, 2002 the Indonesian island of Bali experienced a terrorist attack that rocked the world. It was unquestionably well-coordinated and executed, the largest in the country's history.

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